In a large mixing bowl, combine ground beef, salt, black pepper, garlic powder, and onion powder. Mix gently without overworking the meat. Divide the mixture into 4 equal portions and shape them into patties.

Cook the Patties

Preheat a grill or skillet over medium-high heat. Cook the patties for about 4-5 minutes on one side, then flip them and top each patty with a slice of cheddar cheese. Cook for an additional 3-4 minutes or until the cheese is melted and the burger is cooked to your desired doneness.

Toast the Buns

While the patties are cooking, cut the burger buns in half and toast them lightly on the grill or in a toaster.

Assemble the Burgers

On the bottom half of each toasted bun, place a lettuce leaf, followed by the cooked patty, tomato slices, pickles, ketchup, and mustard. Top with the other half of the bun.

Serve

Serve the burgers hot with your choice of sides like fries or salad.